Systematic review of innate immune responses against <i>Mycobacterium tuberculosis</i> complex infection in animal models.

ABSTRACT:

Background

Mycobacterium tuberculosis (Mtb) complex (MTBC) includes ten species that affect mammals and pose a significant global health concern. Upon infection, Mtb induces various stages in the host, including early bacterial elimination, which may or may not involve memory responses. Deciphering the role of innate immune responses during MTBC infection is crucial for understanding disease progression or protection. Over the past decade, there has been growing interest in the innate immune response to Mtb, with new preclinical models emerging.

Methods

We conducted a systematic review following PRISMA guidelines, focused on innate immune mediators linked to protection or disease progression in animal models of MTBC infection. We searched two databases:

SUBMITTER: Nieto Ramirez LM 

PROVIDER: S-EPMC11821578 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature