Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview.

ABSTRACT: Recent technological advances in intracranial brain stimulation have enhanced the potential of neuromodulation for addressing neuropsychiatric disorders. We present a review of the methodology and the preliminary outcomes of the pioneering studies exploring intracranial biomarker detection and closed-loop neuromodulation to modulate high-symptom severity states in neuropsychiatric disorders. We searched PubMed, Scopus, Web of Science, Embase, and PsycINFO/PsycNet, followed by the reference and citation lists of retrieved articles. This search strategy yielded a total of 583 articles, of which 5 articles met the inclusion criteria, focusing on depression, obsessive-compulsive disorder, post-traumatic stress disorder, and binge eating disorder. We discuss the methodology of biomarker identif

SUBMITTER: Langbein J 

PROVIDER: S-EPMC11821593 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature