NEK4: prediction of available drug targets and common genetic linkages in bipolar disorder and major depressive disorder.

ABSTRACT:

Background

Bipolar disorder (BD) is a mental illness characterized by alternating episodes of elevated mood and depression, while major depressive disorder (MDD) is a debilitating condition that ranks second globally in terms of disease burden. Pharmacotherapy plays a crucial role in managing both BD and MDD. We investigated the genetic differences in populations of individuals with MDD and BD, and from a genetic perspective, we offered new insights into potential drug targets. This will provide clues to potential drug targets.

Methods

This study employed genome-wide association studies (GWAS) and summary-data-based Mendelian randomization (SMR) methods to investigate the genetic underpinnings of patients with bipolar disorder (BD) and major depressive disorder (MDD) and to

SUBMITTER: Gong B 

PROVIDER: S-EPMC11821612 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature