Temporal and geographical dynamics of early-onset Parkinson's disease burden: insights from the Global Burden of Disease Study 2021.

ABSTRACT:

Introduction

Early-onset Parkinson's disease (EOPD) is a rare degenerative condition of the nervous system that primarily affects individuals of working age. Its distinct clinical and genetic features make it a critical area of study in neurological research and public health.

Methods and materials

This analysis utilized data from the Global Burden of Disease Study 2021, covering 371 diseases and injuries across 204 countries and territories from 1990 to 2021. The study focused on individuals aged 15-49 to characterize EOPD. Data on occurrence, frequency, mortality, and disability-adjusted life years (DALYs) were collected. Sociodemographic measures were used to analyze patterns and differences. Statistical methods, including joinpoint regression and decomposition analysis,

SUBMITTER: Li Y 

PROVIDER: S-EPMC11821659 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature