Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters.

ABSTRACT: Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances of concern among the broad chemical universe under REACH. Such grouping is usually based on shared structural features and should only be used for the prioritization objectives. However, additional considerations (as well as structural similarity) are needed, e.g., mode of action, metabolic pathways, chemical reaction products and physicochemical properties, when regulatory management measures are considered (such as restriction, harmonized classification and labeling). Guidance documents from the European Chemicals Agency (ECHA) recommend considering toxicokinetic information to enhance the robustness of the grouping; however, examples of this approach are lacking. Th

SUBMITTER: Najjar A 

PROVIDER: S-EPMC11821685 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature