Enhancing cardiac repair post-myocardial infarction: a study on GATM/Gel hydrogel therapeutics.

ABSTRACT:

Background and purpose

Significant advancements in therapeutic approaches are imperative to address the prevalent impact of myocardial infarction (MI) on morbidity and mortality rates worldwide. This study explores the therapeutic potential of GATM/Gel hydrogel, focusing on its ability to enhance cardiac repair and functionality after MI through modulation of inflammatory and repair pathways.

Experimental approach

The effects of GATM/Gel hydrogel on cardiac recovery were studied in a murine MI model. HA-CHO and gelatin solutions were mixed in situ using a dual syringe with a static mixing needle, and the resulting hydrogel was applied directly to the epicardium during MI modeling, followed by repositioning of the heart and closure of the thorax. Comprehensive in vivo assessm

SUBMITTER: Li T 

PROVIDER: S-EPMC11821695 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature