Roles of efflux pumps and nitroreductases in metronidazole-resistant Trichomonas vaginalis.

ABSTRACT: Trichomonas vaginalis infections significantly impact public health and are associated with increased likelihood of HIV infection, prostate cancer, and pregnancy complications. Current treatment relies almost exclusively on 5-nitroimidazoles, particularly metronidazole, raising concerns about drug resistance and treatment efficacy. This study is aimed at evaluating the effectiveness of metronidazole and tinidazole on metronidazole-resistant strains of T. vaginalis and at determining whether efflux pump inhibitors could reverse metronidazole resistance. Additionally, the roles of nitroreductases in metronidazole resistance were also studied. Metronidazole and tinidazole were tested on both metronidazole-sensitive and -resistant T. vaginalis strains. A checkerboard assay was conducted to ass

SUBMITTER: Paunkov A 

PROVIDER: S-EPMC11821713 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature