Organ development in growth-restricted fetuses in the reduced uterine perfusion pressure rat model: A vascular approach of brain, heart, and kidney.

ABSTRACT: Fetal growth restriction (FGR) increases the risk of developing cardiovascular, renal, and neurovascular diseases. An overlapping vascular pathophysiology as a response to chronic hypoxia and circulatory redistribution in utero, might underlie this lifelong burden. This study aims to assess potential vascular detoriations in multiple organs following FGR using the Reduced Uterine Perfusion Pressure (RUPP) rat model. The fetal brain, heart, and kidney were collected (RUPP n = 16 vs. sham n = 13) at embryonic day (E)19 for histological assessment of various aspects of vascular and structural development. Results indicated similar microvascularisation in all organs between the groups. Structural assessment demonstrated a decreased brain area and thickness of the somatosensory cortex and thick

SUBMITTER: Alhama-Riba J 

PROVIDER: S-EPMC11821727 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature