Finite Element Simulation of Opening Angle Response of Porcine Aortas Using Layer Specific GAG Distributions in One and Two Layered Solid Matrices.

ABSTRACT:

Purpose

Recent studies have identified an effect of glycosaminoglycans (GAG) on residual stresses in the aorta, underscoring the need to better understand their biomechanical roles.

Methods

Aortic ring models for each of the ascending, arch and descending thoracic regions of the porcine thoracic aorta were created in FEBioStudio, using a framework that incorporates the Donnan osmotic swelling in a porous solid matrix. The distribution of fixed charge densities (FCD) through the thickness of the tissue was prescribed as calculated from experimentally quantified sulfated GAG mural distributions. Material parameters for the solid matrix, modeled using a Holmes-Mow constitutive law, were optimized using data from biaxial tensile tests. In addition to modelling the solid matrix a

SUBMITTER: Ghadie NM 

PROVIDER: S-EPMC11821734 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature