The edible ethanol extract of <i>Rosa hybrida</i> suppresses colon cancer progression by inhibiting the proliferation-cell signaling-metastasis axis.

ABSTRACT:

Background/objectives

Rosa hybrida has been demonstrated to exert biological effects on several cell types. This study investigated the efficacy of the edible ethanol extract of R. hybrida (EERH) against human colorectal carcinoma cell line (HCT116) cells.

Materials/methods

HCT116 cells were cultured with different concentrations of EERH (0, 400, 600, 800, and 1,000 µg/mL) in Dulbecco's modified Eagle medium. Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide and viable cell counting assays. Cell cycle pattern was observed by flow cytometry analysis. The wound-healing migration assay, invasion assay, and zymography were used to determine the migratory and invasive level of HCT116 cells treated with EERH. The prot

SUBMITTER: Kim HM 

PROVIDER: S-EPMC11821778 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature