Anti-obesity effects of ethanol extract of green <i>Citrus junos</i> peel enriched in naringin and hesperidin <i>in vitro</i> and <i>in vivo</i>.

ABSTRACT:

Background/objectives

Green Citrus junos (yuja) peel extract has higher naringin and hesperidin contents and antioxidant activity than yellow yuja peel extract, but its anti-obesity effects are unclear. This study examined the anti-obesity properties of green yuja peel ethanol extract (GYE) in 3T3-L1 cells and high-fat diet (HFD)-induced obese mice.

Materials/methods

The effects of GYE on adipocyte differentiation were assessed by measuring Oil red O staining, mRNA and protein expression. The beneficial effects of GYE on HFD-induced obese mice were evaluated using the body weight, body composition, visceral fat size, and biochemical analysis.

Results

GYE inhibited adipocyte differentiation and lipid accumulation compared to the control cells, as evidenced by Oi

SUBMITTER: Heo YJ 

PROVIDER: S-EPMC11821779 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature