Deciphering the stromal molecular landscape: the correlation between p16 and α-SMA in epithelial ovarian cancer.

ABSTRACT:

Introduction

The tumor microenvironment (TME) plays an essential role in promoting cancer initiation, progression and metastasis. Cancer-associated fibroblasts (CAFs) are a major constituent of the TME, but universal CAFs' markers have not yet been identified. We selected several new biomarkers [p16 and α-smooth muscle actin (α-SMA)] to investigate the molecular landscape in epithelial ovarian cancer (EOC), given to the unique TME of this malignancy.

Methods

In total, 64 patients with a diagnosis of EOC who underwent primary debulking surgery (PDS) at the Department of Gynecology and Obstetrics of the University of Pisa were enrolled between January 2019 and June 2021. The stromal expression of α-SMA and p16 was investigated by using immunohistochemistry, and the correlation

SUBMITTER: Caretto M 

PROVIDER: S-EPMC11821793 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature