Rapid and sustained antidepressant effects of tubastatin A in a mouse model of depression.

ABSTRACT: Depression is a prevalent mental disorder and a leading risk factor for suicide. Conventional antidepressants, which target the monoaminergic system, often have delayed therapeutic effects and limited efficacy. Therefore, the development of faster-acting and more effective treatments is critical. We previously showed that a single dose of an histone deacetylase 6 (HDAC6) inhibitor reduced behavioral despair in wild-type mice, suggesting the therapeutic potential of HDAC6 inhibition. In this study, we evaluated the effects of tubastatin A (TubA), a selective HDAC6 inhibitor, in a chronic corticosterone-induced mouse model of depression. Behavioral assessments using the female-encounter test and forced swim test revealed that a single dose of TubA reversed anhedonia within 24 h, with effects

SUBMITTER: Fukada M 

PROVIDER: S-EPMC11821892 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature