Deciphering the functional roles of PE18 and PPE26 proteins in modulating <i>Mycobacterium tuberculosis</i> pathogenesis and immune response.

ABSTRACT:

Introduction

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality worldwide. A crucial factor in Mtb's virulence is the ESX-5 secretion system, which transports PE/PPE proteins such as PE18 and PPE26. These proteins modulate host-pathogen interactions, immune responses, and intracellular survival mechanisms. Despite their importance, the roles and molecular interactions of PE18 and PPE26 in Mtb pathogenesis require further investigation.

Methods

We explored the roles of PE18 and PPE26 using recombinant Mycobacterium smegmatis (Msmeg) as a model organism. Protein-protein interactions were analyzed biochemically to identify partners within the ESX-5 secretion system, including EspG5 and other PE/

SUBMITTER: Ehtram A 

PROVIDER: S-EPMC11821933 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature