Impact of platelet transfusion and bleeding risk stratification in patients with immune thrombocytopenia before procedures.

ABSTRACT: The main treatment goal for immune thrombocytopenia (ITP) is bleeding risk reduction, particularly during procedures. While adjusting platelet thresholds with ITP treatments is recommended, platelet transfusions are commonly used despite controversial benefits. We evaluated the effectiveness of platelet transfusion in reducing post-procedure bleeding risk and identified predictive indicators of bleeding. A nationally representative database was used to develop a model predicting post-procedure bleeding risk in patients with ITP. Machine learning analyses, including random forest feature importance and Shapley additive explanations (SHAP) values, assessed 34 risk factors, including the platelet transfusion amount. The random forest model had an area under the receiver-operating characterist

SUBMITTER: Kang KW 

PROVIDER: S-EPMC11822007 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature