Suicidal risk is associated with hyper-connections in the frontal-parietal network in patients with depression.

ABSTRACT: Suicide is a complex behavior strongly associated with depression. Despite extensive research, an objective biomarker for evaluating suicide risk precisely and timely is still lacking. Using the precision resting-state fMRI method, we studied 61 depressive patients with suicide ideation (SI) or suicide attempt (SA), and 35 patients without SI to explore functional biomarkers of suicide risk. Among them, 21 participants also completed electroconvulsive therapy (ECT) treatment, allowing the examination of functional changes across different risk states within the same individual. Functional networks were localized in each subject using resting-state fMRI and then an individualized connectome was constructed to represent the subject's functional brain organization. We identified a set of conn

SUBMITTER: Ren Y 

PROVIDER: S-EPMC11822010 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature