Intercellular adhesion boots collective cell migration through elevated membrane tension.

ABSTRACT: In multicellular systems, the migration pattern of individual cells critically relies on the interactions with neighboring cells. Depending on the strength of these interactions, cells either move as a collective, as observed during morphogenesis and wound healing, or migrate individually, as it is the case for immune cells and fibroblasts. Mediators of cell-cell adhesions, such as cadherins coordinate collective dynamics by linking the cytoskeleton of neighboring cells. However, whether intercellular binding alone triggers signals that originate from within the plasma membrane itself, remains unclear. Here, we address this question through artificial photoswitchable cell-cell adhesions that selectively connect adjacent plasma membranes without linking directly to cytoskeletal elements. We

SUBMITTER: Bijonowski BM 

PROVIDER: S-EPMC11822051 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature