An experimental and computational investigation of executive functions and inner speech in schizophrenia spectrum disorders.

ABSTRACT: Flexible goal-directed human cognition is supported by many forms of self-directed manipulation of representations. Among them, Inner-Speech (IS; covert self-directed speech) acts on second-order representations (e.g., goals/sub-goals), empowering attention and feedback processing. Interestingly, patients with Schizophrenia Spectrum Disorders (SSD) show impaired Executive Functions (EF; e.g., cognitive flexibility) and, probably, a related IS alteration. However, fragmentary evidence and no computational modeling prevent a clear assessment of these processes and focused therapeutic interventions. Here, we address these issues by exploiting a translational approach that integrates experimental clinical data, machine learning, and computational modeling. First, we administered the Wisconsin

SUBMITTER: Granato G 

PROVIDER: S-EPMC11822060 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature