Unveiling a novel model of cell senescence-related genes for prognostic assessment and immunotherapeutic insights in gastric cancer.

ABSTRACT: Recent studies have shed light on the dysregulated nature of cell senescence in many cancers, with implications for tumor immunity and prognosis. However, it is still unclear what role cellular senescence plays in stomach adenocarcinoma (STAD). To address this gap, we investigated the impact of cellular senescence on gastric cancer and its potential prognostic and therapeutic significance. The mRNA expression patterns, gene mutations, and clinical information of STAD were obtained from the cancer genome atlas (TCGA) and gene expression omnibus (GEO). Differentially expressed senescence-related genes were identified between gastric cancer tissues and normal tissues, then the prognostic value and functional roles of these genes in immunotherapy were systematically investigated by bioinformat

SUBMITTER: Wang G 

PROVIDER: S-EPMC11822064 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature