Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer's disease.

ABSTRACT: In Alzheimer's disease (AD), Aβ triggers p-tau secretion, which drives tau aggregation. Therefore, it is critical to characterize modulators of Aβ-related p-tau increases which may alter AD trajectories. Here, we assessed whether factors known to alter tau levels in AD modulate the association between fibrillar Aβ and secreted p-tau₁₈₁ determined in the cerebrospinal fluid (CSF). To assess potentially modulating effects of female sex, younger age, and ApoE4, we included 322 ADNI participants with cross-sectional/longitudinal p-tau₁₈₁. To determine effects of microglial activation on p-tau₁₈₁, we included 454 subjects with cross-sectional CSF sTREM2. Running ANCOVAs for nominal and linear regressions for metric variables, we found that women had higher Aβ-re

SUBMITTER: Biel D 

PROVIDER: S-EPMC11822105 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature