Comparison of dermal and eschar fibroblasts in full skin equivalents.

ABSTRACT: Full-thickness burn wounds pose significant problems, demanding specialised therapies to avoid complications and promote recovery. Eschar tissue, which forms in response to severe burns, contains viable fibroblasts, which migrate from the surrounding tissue in response to burn injury and exhibit a myofibroblast phenotype. The goal of this study was to characterise eschar-derived fibroblasts and examine their use for engineered in vitro full skin equivalents in comparison to normal dermal fibroblasts, which were harvested from non-injured skin. Microarray analysis indicated that eschar fibroblasts differ from dermal fibroblasts in various biological processes including inflammation, extracellular matrix formation, cell migration and differentiation. Skin equivalents with eschar fibroblasts

SUBMITTER: Kutluoglu GC 

PROVIDER: S-EPMC11822215 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature