Disease activity of rheumatoid arthritis and kidney function decline: a large prospective registry study.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) is a common comorbidity of rheumatoid arthritis (RA). The association of longitudinal RA disease activity with long-term kidney function has remained uncertain.

Method

We analysed a multicentre prospective RA registry in the USA from 2001 to 2022. The exposure was updated time-averaged Clinical Disease Activity Index (TA-CDAI) categories from study enrolment. The primary outcome was a longitudinal estimated glomerular filtration rate (eGFR) change. Secondary outcomes included developments of CKD stage G3a (eGFR<60 mL/min/1.73 m²) and stage G3b (eGFR<45 mL/min/1.73 m²). Results were adjusted for relevant time-fixed and time-varying covariates.

Results

31 129 patients (median age: 58.0 years, female: 76.3%,

SUBMITTER: Fukui S 

PROVIDER: S-EPMC11822225 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature