Clinically meaningful eGFR slope as a surrogate endpoint differs across CKD stages and slope evaluation periods: the CKD-JAC study.

ABSTRACT:

Background

The slope of estimated glomerular filtration rate (eGFR) is a promising surrogate endpoint in patients with chronic kidney disease (CKD). However, current evidence is mainly derived from Western populations with CKD stages 1-3. In addition, stage-by-stage analysis has never been formally performed.

Methods

We analyzed data from the Chronic Kidney Disease Japan Cohort Study, which included a large proportion of patients with CKD stages 4 and 5. We estimated eGFR slopes over three evaluation periods (0.5, 1, and 2 years) using mixed effects models and examined their associations with kidney failure with replacement therapy across CKD stages.

Results

Of 2713 patients with an available 1-year eGFR slope, 985 subsequently initiated kidney replacement therapy. Ov

SUBMITTER: Imaizumi T 

PROVIDER: S-EPMC11822292 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature