Immunoglobulin unresponsive Guillain-Barre syndrome: rinse or repeat? A systematic review.

ABSTRACT:

Introduction

Severe Guillain-Barré syndrome (GBS) patients may not show improvement after a single course of intravenous immunoglobulin (IVIg) therapy. Current treatment options include either a second course of IVIg or therapeutic plasma exchange (TPE). This systematic review aims to evaluate the current literature on the use of a second course of IVIg or TPE in patients who fail to show clinical improvement after the first IVIg course.

Methods

We searched PubMed, Embase and Medline databases up until 26 October 2023. Studies that evaluated adult patients with confirmed GBS who have failed one full course of IVIg and subsequently received either repeat IVIg or TPE were included. Risk of bias was performed using study-specific checklists. A narrative synthesis of results is

SUBMITTER: Roe T 

PROVIDER: S-EPMC11822392 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature