Single-Cell Analysis of Endothelial Cell Injury in IgA Nephropathy.

ABSTRACT:

Background

The precise mechanisms responsible for renal injury in IgA nephropathy (IgAN) are not fully understood. Our study employed an extensive scRNA-seq analysis of kidney biopsies obtained from individuals with IgAN, with a specific emphasis on investigating the involvement of renal endothelial cells.

Methods

We obtained data from the Gene Expression Omnibus database and conducted bioinformatics analysis, which included enrichment analysis of differentially expressed genes, AUCell analysis, and high-dimensional weighted gene co-expression network analysis (hdWGCNA). The results of these analyses were further validated using human renal glomerular endothelial cells (HRGECs).

Results

The ScRNA-seq data uncovered notable variations in gene expression between IgAN an

SUBMITTER: Yang YC 

PROVIDER: S-EPMC11822453 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature