CSF production rate, resistance to reabsorption, and intracranial pressure: a systematic review and meta-analysis.

ABSTRACT: Davson's equation relates the state of stable intracranial pressure (ICP) to the production rate of CSF (I_F) and resistance to CSF outflow (R_OUT). Both parameters are assumed to be independent of ICP, but results are conflicting. The objective is to define the relationship between ICP, I_F and R_OUT using a systematic literature review. Medline and Embase were searched from inception up to 12 February 2024. Experimental studies exploring the association between ICP, I_F, and R_OUT were included. Individual measurements of ICP, I_F and/or R_OUT were extracted from tables or graphs, alongside descriptive parameters (population, ICP measurement site, disease, and computational method). Linear regression and mixe

SUBMITTER: Olakorede I 

PROVIDER: S-EPMC11822472 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature