Research Domain Criteria in NIMH Grants Characterized Using Large Language Models.

ABSTRACT:

Importance

Over the past decade, the leadership of the National Institute of Mental Health (NIMH) has emphasized the importance of a transdiagnostic approach to psychiatric investigation using Research Domain Criteria (RDoC) mapping more closely to neurobiology.

Objective

To investigate whether research support from the NIMH for individual RDoC domains and for transdiagnostic investigation has changed over time and has had differential impact in terms of publication, citations, or patent filings.

Design, setting, and participants

In this longitudinal cohort study, all R01, R21, and R03 studies funded by the NIMH between January 2003 and December 2023 were identified via the National Institutes of Health RePORTER database. Their abstracts were characterized in terms of

SUBMITTER: Perlis RH 

PROVIDER: S-EPMC11822550 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature