Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease.

ABSTRACT: Age-related macular degeneration (AMD) is a complex multifactorial disease that affects the central region of the retina. AMD is clinically heterogeneous, leading to geographic atrophy (GA) and/or choroidal neovascularization (CNV) at advanced stages. Considerable data exists in support of a genetic predisposition for AMD. Recent linkage studies have provided evidence in favor of several AMD susceptibility loci. We have performed a high-resolution (5-cM) genome scan of 412 affected relative pairs that were enriched for late-stage disease (GA and/or CNV). Nonparametric linkage analysis was performed using two different diagnostic criteria and also by dividing the affected individuals according to GA or CNV phenotype. Our results demonstrate evidence of linkage in regions that were suggested

SUBMITTER: Abecasis GR 

PROVIDER: S-EPMC1182262 | biostudies-literature | 2004 Mar

REPOSITORIES: biostudies-literature