Aging alters the effect of adiponectin receptor signaling on bone marrow-derived mesenchymal stem cells.

ABSTRACT: Adiponectin receptor signaling represents a promising therapeutic target for age-related conditions such as osteoporosis and diabetes. However, the literature presents conflicting evidence regarding the role of adiponectin signaling in bone homeostasis and fracture repair across different health states, ages, and disease conditions. These inconsistencies may arise from the complex endocrine and paracrine feedback mechanisms regulating adiponectin, as well as the variability in adiponectin isoforms and receptor expressions. In this study, we observed differential expression of adiponectin receptors in the bone marrow (BM) of aged mice, characterized by elevated levels of adiponectin receptor 2 and reduced levels of receptor 1, as corroborated by both single-cell sequencing and in vivo stain

SUBMITTER: Liu H 

PROVIDER: S-EPMC11822658 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature