The N6-methyladenosine landscape of ovarian development and aging highlights the regulation by RNA stability and chromatin state.

ABSTRACT: The versatile epigenetic modification known as N6-methyladenosine (m⁶A) has been demonstrated to be pivotal in numerous physiological and pathological contexts. Nonetheless, the precise regulatory mechanisms linking m⁶A to histone modifications and the involvement of transposable elements (TEs) in ovarian development and aging are still not completely understood. First, we discovered that m⁶A modifications are highly expressed during ovarian aging (OA), with significant contributions from decreased m⁶A demethylase FTO and overexpressed m⁶A methyltransferase METTL16. Then, using FTO knockout mouse model and KGN cell line, we also observed that FTO deletion and METTL16 overexpression significantly increased m⁶A levels. This le

SUBMITTER: Hu X 

PROVIDER: S-EPMC11822672 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature