New Antimicrobial Cyclodepsipeptides from a Freshwater Fungus from the Sierra Madre Oriental in Mexico.

ABSTRACT: The Sierra Madre Oriental (SMO) in Mexico is a complex, unexplored geological area with multiple habitats and unique physical, chemical, and biological features. A bioactive-guided study of the organic extract from a solid-state fermentation culture from a taxonomically unidentified fungus isolated from submerged wood in the waterfall "El Caracol", Nuevo Leon, at the SMO, led to the identification of three new cyclodepsipeptides (1-3) and the known Sch 217048 (4) and Sch 378161 (5). Structures of all compounds were elucidated by spectroscopic and spectrometric methods. The isolated compounds 4 and 5 showed antimicrobial activity against Gram-positive strains and the Gram-negative Acinetobacter baumannii ATCC 17978, including multidrug-resist

SUBMITTER: Yeverino IR 

PROVIDER: S-EPMC11822689 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature