Synthesis and Characterization of Glycosaminoglycan Mimetic Variants to Promote Chondrogenesis.

ABSTRACT: Tissue engineering strategies to treat cartilage damage remain inadequate because of the difficulty in regenerating fully functional cartilage tissue. Sulfated glycosaminoglycans (GAGs), which are found in the native extracellular matrix, are known to interact with growth factors and, thus, promote chondrocyte function. Native GAGs have been explored as viable scaffold materials for tissue repair applications. However, it is unclear what structural features in GAGs are critical for promoting chondrogenesis. Therefore, this study generated GAG mimetics that vary in glycosidic linkage geometry and monomer ring substitution and were evaluated for their effect on mesenchymal stem cell (MSC) chondrogenesis and their potential use in cartilage tissue engineering applications. GAG mimetics were s

SUBMITTER: Vincent R 

PROVIDER: S-EPMC11822690 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature