Biodistribution of ⁸⁹Zr-Radiolabeled Nanoassemblies for Monoclonal Antibody Delivery Revealed through <i>In Vivo</i> PET Imaging.

ABSTRACT: Despite the outstanding performance of monoclonal antibodies (mAbs) in the clinic, their full potential has been hindered due to their inability to cross cell membranes and therefore reach intracellular targets. The use of nanotechnology to deliver mAbs to intracellular domains has been highlighted as a strategy with high potential. Working toward this goal, we have recently developed and validated palmitoyl hyaluronate (HAC16)-based nanoassemblies (HANAs), a novel technology for the intracellular delivery of mAbs in Kirsten Rat Sarcoma Virus (KRAS)-mutated tumors, one of the most prevalent and a challenging intracellular oncoprotein. Despite their success, the pharmacokinetics and biodistribution of these delivery vehicles are still unknown due to their chemical complexity, a challenge co

SUBMITTER: Lopez-Estevez AM 

PROVIDER: S-EPMC11822718 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature