Psoriasis and dementia: A population-based matched cohort study of adults in England.

ABSTRACT:

Objective

Evidence for an association between psoriasis and dementia is limited and conflicting. We aimed to investigate the association using large and representative population-based data and describe risk by dementia subtype and over time.

Methods

We compared dementia risk between people with and without psoriasis using an age-, sex- and primary care practice-matched cohort of adults aged ≥40 years from the Clinical Practice Research Datalink Aurum in England (1997-2021) linked to hospital admissions data, analysed with stratified Cox regression.

Results

Among 360,014 individuals with psoriasis and 1,799,617 without, psoriasis was associated with a small increased risk of all-cause dementia (adjusted hazard ratio [aHR] 1.06, 95% CI 1.04-1.08; absolute rate differen

SUBMITTER: Matthewman J 

PROVIDER: S-EPMC11822786 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature