Phenotypic and oncological insights in ANNA1 autoimmunity: Age stratification and biomarker analysis.

ABSTRACT:

Objective

To describe the phenotypes, oncological associations, biomarker profiles, and outcomes across different age groups in patients with ANNA1 (anti-Hu) autoimmunity.

Methods

A retrospective review of patients with ANNA1-IgG in serum/CSF between January 1, 2001, and December 31,2019 was performed. Patients were classified into three groups based on the age of symptom onset. Phage immunoprecipitation sequencing (PhIP-Seq) and neurofilament light chain (NfL) measurements were done in patient sera/CSF with archived samples.

Results

Of 122 patients, 81 (66%), 20 (16%), and 21 (17%) patients belonged to older adults, young adults, and pediatric groups, respectively. Lung cancer and neuromuscular presentations were more common in older adults (p < 0.001), while limbic

SUBMITTER: Paramasivan NK 

PROVIDER: S-EPMC11822791 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature