APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia.

ABSTRACT:

Objective

Recent work has bolstered the possibility that peripheral changes may be relevant to Alzheimer's disease pathogenesis in the brain. While age-associated blood-borne proteins have been targeted to restore function to the aged brain, it remains unclear whether other dysfunctional systemic states can be exploited for similar benefits. Here, we investigate whether APOE allelic variation or presence of brain amyloid are associated with plasma proteomic changes and the molecular processes associated with these changes.

Methods

Using the SOMAscan assay, we measured 1305 plasma proteins from 53 homozygous, APOE3 and APOE4 subjects without dementia. We investigated the relationship of either the APOE-ε4 allele or amyloid positivity with plasma proteome changes by linear mix

SUBMITTER: Philippi SM 

PROVIDER: S-EPMC11822792 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature