Progressive brain atrophy and cortical reorganization related to surgery in temporal lobe epilepsy.

ABSTRACT:

Objective

Epilepsy is associated with progressive cortical atrophy exceeding normal aging. We aimed to explore longitudinal cortical alterations in patients with temporal lobe epilepsy (TLE) and distinct surgery outcomes.

Methods

We obtained longitudinal T1-weighted MRI data in a well-designed cohort, including 53 operative TLE patients, 23 nonoperative TLE patients, and 23 healthy controls. According to seizure outcomes at 24 months after surgery, operative patients were divided into seizure-free (SF) and nonseizure-free (NSF) group. Operative patients were scanned before and after surgery, while nonoperative patients and healthy controls were rescanned with similar interval times. We measured gray matter volume (GMV) in all participants and compared longitudinal cortical a

SUBMITTER: Li W 

PROVIDER: S-EPMC11822803 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature