Melatonin alleviates oral epithelial cell inflammation via Keap1/Nrf2 signaling.

ABSTRACT:

Background

Oral mucosal diseases manifest primarily as inflammatory conditions. These diseases affect approximately half a billion people worldwide.

Objective

Novel and effective strategies for treating inflammatory diseases of the oral mucosa have great potential for improving patient outcomes, and warrant study.

Methods

The impact of melatonin on inflammation was investigated using RAW264.7 macrophages and HOEC and HSC-3 oral epithelial cells.

Results

Melatonin decreased macrophage-induced inflammation by acting through the melatonin receptor MTNR1A. Additionally, melatonin mitigated macrophage-induced inflammation in oral epithelial cells. Importantly, the results demonstrated that the effects of melatonin on oral epithelial inflammation were mediated throug

SUBMITTER: Zhang N 

PROVIDER: S-EPMC11822817 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature