Interaction between intubation and stress regarding hemodynamic and hormonal changes.

ABSTRACT:

Objective

To compare the efficacy of dexmedetomidine and fentanyl to reduce hemodynamic and biochemical stress markers associated with endotracheal intubation under general anesthesia.

Methods

We performed a prospective randomized controlled study of 80 patients and 20 healthy controls at Assiut University from January to June 2024. The patients were allocated to two groups: Group D received dexmedetomidine and Group F received fentanyl. Blood samples were collected at four time points: T0 (baseline), T1 (2 minutes after induction of anesthesia), T2 (1 minute after intubation), and T3 (10 minutes post-intubation), for stress marker analysis.

Results

Intubation significantly increased stress markers in both groups compared to baseline. Group D showed significantly lowe

SUBMITTER: Abd Elhafez NF 

PROVIDER: S-EPMC11822838 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature