Meta-analysis of <i>EGFR</i> gene polymorphisms and lung cancer risk.

ABSTRACT:

Objective

This meta-analysis aims to systematically evaluate the associations of four specific Single Nucleotide Polymorphisms (SNPs)-rs712829, rs712830, rs11568315, and rs884225-located in the promoter, intronic, and 3' untranslated regions (3'UTR) of the EGFR gene, with lung cancer risk.

Introduction

The associations between EGFR gene polymorphisms and lung cancer risk is a topic of ongoing debate, which is still deemed controversial. Despite numerous studies, results are inconsistent.

Methods

We conducted a comprehensive literature search across the PubMed, Science Direct, and Web of Science databases to identify relevant case-control studies examining the association between EGFR gene polymorphisms and lung cancer risk.

Results

From an initial pool of 26,95

SUBMITTER: Fakhkhari M 

PROVIDER: S-EPMC11822845 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature