<i>Mycobacterium abscessus</i> pulmonary infection and associated respiratory function in cystic fibrosis-like βENaC mice.

ABSTRACT:

Introduction

Chronic pulmonary infection with Mycobacterium abscessus (M. abscessus) is a significant cause of morbidity and mortality in people with cystic fibrosis (CF). Developing an animal model of M. abscessus pulmonary infection, especially under CF conditions, is essential to understanding clinical pulmonary M. abscessus infection. βENaC transgenic mice are known to develop spontaneous CF-like disease characterized by airway mucus obstruction and inflammation. The aim of this study was to evaluate the suitability of βENaC mice as a preclinical model and characterize their respiratory function during M. abscessus lung infection.

Methods

Mice received an intrapulmonary aerosol of M. abscessus using a high-pressure syringe device

SUBMITTER: Pearce CM 

PROVIDER: S-EPMC11822858 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature