Casual associations between frailty and nine mental disorders: bidirectional Mendelian randomisation study.

ABSTRACT:

Background

An increasing number of observational studies have reported associations between frailty and mental disorders, but the causality remains ambiguous.

Aims

To assess the bidirectional causal relationship between frailty and nine mental disorders.

Method

We conducted a bidirectional two-sample Mendelian randomisation on genome-wide association study summary data, to investigate causality between frailty and nine mental disorders. Causal effects were primarily estimated using inverse variance weighted method. Several secondary analyses were applied to verify the results. Cochran's Q-test and Mendelian randomisation Egger intercept were applied to evaluate heterogeneity and pleiotropy.

Results

Genetically determined frailty was significantly associa

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11822947 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature