Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank.

ABSTRACT:

Background

Physical activities are widely implemented for non-pharmacological intervention to alleviate depressive symptoms. However, there is little evidence supporting their genotype-specific effectiveness in reducing the risk of self-harm in patients with depression.

Aims

To assess the associations between physical activity and self-harm behaviour and determine the recommended level of physical activity across the genotypes.

Method

We developed the bidirectional analytical model to investigate the genotype-specific effectiveness on UK Biobank. After the genetic stratification of the depression phenotype cohort using hierarchical clustering, multivariable logistic regression models and Cox proportional hazards models were built to investigate the associations betwee

SUBMITTER: Jung J 

PROVIDER: S-EPMC11822987 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature