Association between Heavy metals and triglyceride-glucose-related index: a mediation analysis of inflammation indicators.

ABSTRACT:

Background

In cardiovascular diseases (CVD) and insulin resistance (IR), elevated blood lipids and glucose are common. These abnormalities accelerate atherosclerosis and may impair insulin signaling via oxidative stress and inflammation. The triglyceride-glucose (TyG) index is a cost-effective marker for assessing IR and CVD risk, reflecting insulin resistance and early atherosclerosis. However, research on factors affecting the TyG index, especially mixed heavy metal exposure, is limited. Heavy metals might alter the TyG index by inducing oxidative stress and inflammation, affecting lipid and glucose metabolism. This study explores the link between heavy metal exposure and TyG index changes, focusing on inflammation's mediating role, aiming to offer new strategies for CVD and IR p

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11823045 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature