Histomorphometric and immunohistochemical assessment of treated dentin matrix delivered by platelet-rich fibrin for socket preservation in rabbit model.

ABSTRACT:

Objectives

This study aimed to test treated dentine matrix (TDM) with platelet-rich fibrin (PRF) for socket preservation, following tooth extraction compared to synthetic grafting material Nanobone (NB) with PRF.

Materials and methods

Study was conducted on New Zealand rabbits (n = 40). Bilateral first lower premolar extraction was performed, with one side left empty and the other side filled with (PRF) in one group (n = 20). In the other group (n = 20), one side was filled with TDM/PRF while the other side was filled with NB/ PRF. After one and three months, rabbits were euthanized, and the socket area was examined using haematoxylin and eosin (H&E) and Goldner Masson trichrome stains. One-way ANOVA and post-hoc tests were used for histomorphometric analysis. Immunohistoche

SUBMITTER: Sedek EM 

PROVIDER: S-EPMC11823050 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature