Lipid metabolism of apoptotic vesicles accelerates cutaneous wound healing by modulating macrophage function.

ABSTRACT: The application of apoptotic extracellular vesicles (ApoEVs) derived from stem cell in skin wound healing has garnered significant attention. In recent decades, scholars have shown that extracellular vesicles (EVs) established intercellular communication by carrying proteins or microRNAs, the role of lipids in EVs in wound healing has yet to be clarified. Here, we focus on the key role of group X secretory phospholipase A₂ (sPLA₂-X) in lipid metabolism. Specifically, sPLA₂-X significantly increased the production of the anti-inflammatory lipid mediators, resolvin D5 (RvD5), by hydrolyzing phospholipids in ApoEVs. This change not only promoted the uptake of ApoEVs by macrophages, but also effectively inhibited the expression of tumor necrosis factor-alpha (T

SUBMITTER: Qin Y 

PROVIDER: S-EPMC11823102 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature