Single-cell transcriptome analysis reveals the dysregulated monocyte state associated with tuberculosis progression.

ABSTRACT:

Background

In tuberculosis (TB) infection, monocytes play a crucial role in regulating the balance between immune tolerance and immune response through various mechanisms. A deeper understanding of the roles of monocyte subsets in TB immune responses may facilitate the development of novel immunotherapeutic strategies and improve TB prevention and treatment.

Methods

We retrieved and processed raw single-cell RNA-seq data from SRP247583. Single-cell RNA-seq combined with bioinformatics analysis was employed to investigate the roles of monocytes in TB progression.

Results

Our findings revealed that classical monocytes expressing inflammatory mediators increased as the disease progressed, whereas non-classical monocytes expressing molecules associated with anti-pathogen

SUBMITTER: Ma R 

PROVIDER: S-EPMC11823163 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature