The causal relationship between the gut microbiota and endometrial cancer: a mendelian randomization study.

ABSTRACT:

Background

Gut microbiota is associated with endometrial cancer (EC); however, the causal relationship remains unexplored. This study attempted to explore the relationship between gut microbiota and EC using Mendelian randomization (MR) methods.

Methods

In this two-sample MR analysis, we used MiBioGen's gut microbiota data as the exposure and three datasets from European populations with EC as the outcome. The EC datasets included general EC, endometrioid histology, and non-endometrioid histology. Single nucleotide polymorphism (SNP) was used as the instrumental variable. Inverse variance weighted (IVW), multiplicative random effects IVW (MRE-IVW), Maximum likelihood (ML), MR Egger, MR-PRESSO, and the weighted median were used to perform MR analysis. Sensitivity analysis was

SUBMITTER: Yang C 

PROVIDER: S-EPMC11823214 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature