The role of different LNG-IUS therapies in the management of adenomyosis: a systematic review and meta-analysis.

ABSTRACT:

Objective

To summarize evidence on the efficacy and safety of the levonorgestrel-releasing intrauterine system (LNG-IUS) in managing adenomyosis (AM), both as a monotherapy and in combination with other therapies.

Methods

We searched Medical Literature Analysis and Retrieval System On-Line: Medline, The Cochrane Library, Embase, SinoMed, China National Knowledge Infrastructure, and Wanfang from the inception to Aug 12, 2024 for articles using the LNG-IUS both alone and combined with other therapies in patients with AM. The primary outcome included dysmenorrhea, menstrual bleeding, uterine volume, endometrial thickness and quality of life. The secondary outcome was the assessment of adverse events. Data synthesis was conducted using random-effects model with significant heter

SUBMITTER: Zhang B 

PROVIDER: S-EPMC11823221 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature