Bacterial membrane-modified cerium oxide nanoboosters enhance systemic antitumor effects of radiotherapy in metastatic triple-negative breast cancer.

ABSTRACT:

Background

Radiotherapy plays an important role in the treatment of triple-negative breast cancer, yet its ability to trigger systemic responses against distant tumors remains limited.

Results

To address this challenge, we developed a biomimetic nanobooster by incorporating cerium oxide (CeO₂) nanoparticles with bacterial outer membrane vesicles (OMVs), termed CeO₂@OMV. This innovative strategy overcomes the limitations of conventional radiotherapy by enhancing antigen release and improving immune cell infiltration, thereby amplifying its effectiveness in combating both primary and metastatic tumors. The biocompatibility, antitumor effects, bystander and immunomodulatory impacts of the nanoboosters were assessed by comprehensive in vitro assays and in v

SUBMITTER: Chen SF 

PROVIDER: S-EPMC11823237 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature